Many people ask the nephrologists when to worry about creatinine levels. Creatinine is transported to blood from where it gets excreted by kidneys via urine. In the presence of enzyme creatine kinase, phosphocreatine is produced from creatine resulting in the formation of creatinine as a by-product. From the liver, it is transported to various organs including muscles. Creatine is synthesized mainly in the liver. ![]() ![]() During the breakdown of creatine phosphate, creatinine is produced. ![]() Creatinine is formed during the synthesis process of phosphocreatine.
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